{"id":37719,"date":"2025-01-29T20:03:03","date_gmt":"2025-01-29T10:03:03","guid":{"rendered":"https:\/\/myassignmenthelp.info\/assignments\/?p=37719"},"modified":"2025-01-29T20:03:04","modified_gmt":"2025-01-29T10:03:04","slug":"principles-of-biostatistics-2349447","status":"publish","type":"post","link":"https:\/\/myassignmenthelp.info\/assignments\/principles-of-biostatistics-2349447\/","title":{"rendered":"Principles of Biostatistics-2349447"},"content":{"rendered":"<p><div class=\"ppw-restricted-content\"><\/p>\n\n\n\n<p>For each true-false statement: Replace the small response line with a T or F <strong>(capital, black, bold).<\/strong><\/p>\n\n\n\n<p>Part I True-False Statements: Fill in <strong>T<\/strong>&nbsp;or <strong>F<\/strong>&nbsp;(4 points each)<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>In a regression involving age and serum cholesterol level, the \u201cleast squares\u201d or \u201cbest fit\u201d line calculated from the sample data estimates the age-adjusted mean serum cholesterol level in the population. <strong><u><strong>_F__<\/strong><\/u><\/strong><\/li>\n<\/ol>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>R<sup>2<\/sup>, the coefficient of determination, decreases when a variable is removed from a regression model. <strong><u><strong>_T__<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The following data are from a follow-up study investigating a possible relationship between elevated ferritin levels (>200 \u00b5g\/l) and ischemic stroke:<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>&nbsp;<\/td><td>Exposed<\/td><td>Unexposed<\/td><\/tr><tr><td>Events<\/td><td>56<\/td><td>37<\/td><\/tr><tr><td>Person-time<\/td><td>819<\/td><td>951<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The appropriate procedure for evaluating the significance of such data is the binomial test. <strong><u><strong>_F__<\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The maximum likelihood method is used to estimate parameters in logistic regression?\u00a0<strong><u><strong>_T__<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In a logistic regression model with 2 predictor variables (risk factors A and B) and no interaction term, the estimated relative risk (RR) for subjects exposed to both risk factor A (adjusted RR estimate = 2.0) and risk factor B (adjusted RR estimate = 1.5) is 3.0.\u00a0<strong><u><strong>_F__<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p>Part II Brief Responses (4 points each)<\/p>\n\n\n\n<p>For questions 1 &#8211; 5: Replace the small response line with your letter choice <strong>(capital, black, bold)<\/strong>&nbsp;or fill-in response <strong>(black, bold).<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Part 1: For a fixed sample size: as the number of independent variables in a regression model increases, the power of the regression <strong><u><strong>decreases<\/strong><\/u><\/strong>.<\/li>\n<\/ol>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ol style=\"list-style-type:lower-alpha\" class=\"wp-block-list\">\n<li>increases<\/li>\n<\/ol>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><u><strong>decreases<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<p>Part 2: When a potential confounding variable is found not to affect the \u03b2-coefficient estimate for the variable of interest in a regression model and is therefore removed from the model, the coefficient of determination (R<sup>2<\/sup>) <strong><u><strong>decreases<\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p>a) increases<\/p>\n\n\n\n<p>b)<strong><u><strong> <\/strong><\/u><\/strong><strong><u><strong>decreases<\/strong><\/u><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>An F-test for <strong><u><strong>homogeneity of variances (i.e. Bartlett&#8217;s test)<\/strong><\/u><\/strong>\u00a0must be performed prior to conducting an analysis of covariance (ANCOVA).<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Part 1: Under what circumstances are chi-square tests biased? <strong><u><strong>all of the above<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ol style=\"list-style-type:lower-alpha\" class=\"wp-block-list\">\n<li>if any expected value is less than 1.0 or > 20% of the expected values are less than 5.0<\/li>\n<\/ol>\n\n\n\n<ul class=\"wp-block-list\">\n<li>small sample size<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>when there is 1 degree of freedom<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><u><strong>all of the above<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<p>Part 2: What is the best statistical test to apply when dealing with simple case-control data (single 2 x 2 table)? _<strong><u><strong>Fisher exact test__<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong><u><strong>XXX<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<ol style=\"list-style-type:lower-alpha\" class=\"wp-block-list\">\n<li>chi-square test<\/li>\n<\/ol>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><u><strong>fisher exact test<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>binomial test<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Refer to the figure below:<\/li>\n<\/ul>\n\n\n\n<p>Part 1: What is the estimated mean SBP for age 40? <strong><u><strong>__130________<\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p>Part 2: What is the estimated mean SBP for age 10? __<strong><u><strong>100________<\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image.png\"><img loading=\"lazy\" decoding=\"async\" width=\"309\" height=\"230\" src=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image.png\" alt=\"\" class=\"wp-image-37720\" srcset=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image.png 309w, https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-300x223.png 300w\" sizes=\"auto, (max-width: 309px) 100vw, 309px\" \/><\/a><\/figure>\n\n\n\n<ol class=\"wp-block-list\">\n<li>As health commissioner of city B you have decided to implement a $10 million exercise program if results from a recently concluded cohort study in 2,000 males aged 40-59 years showed there was 95% confidence (exact binomial) that the relative risk (RR) among subjects with a baseline resting heart rate (HR) > 80 beats\/min vs. those with a baseline resting HR \u2264 80 beats\/min was different from 1.50. \u00a0The estimated RR from the study was 2.61 (<em>X<\/em><sup>2 <\/sup>= 13.431).<\/li>\n<\/ol>\n\n\n\n<p>After calculating a test-based 95% confidence interval for the estimated RR in the space below: What is your decision? __<strong><u><strong>Implement the program_<\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ol style=\"list-style-type:lower-alpha\" class=\"wp-block-list\">\n<li><strong><u><strong>Implement the program.<\/strong><\/u><\/strong><\/li>\n<\/ol>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Do not implement the program.<\/li>\n<\/ul>\n\n\n\n<p>For questions 6 &#8211; 7: Replace the response line with your brief statement <strong>(black, bold).<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Part 1: Name one limitation when using the Mantel-Haenszel method to control for confounding in case-control studies.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u><strong>The method is intricate and demands a relatively large sample size in situations where there is more than one confounder because of the high number of strata<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<p>Part 2: Name one limitation when using matching to control for confounding in a case-control study?<\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u><strong>The method can lead to over-adjustment and even introduce confounding. Also, matching can create selection bias when used for non-confounders. &nbsp;<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Name 2 types of censoring that can occur during follow-up in a cohort study or clinical trial.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p>1. <strong><u><strong>Right censoring<\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong><u><strong>2. Left censoring<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<p>For question 8: Replace the small response line with your letter choice <strong>(capital, black, bold).<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A potential confounding variable should be included in a multiple proportional hazards regression model if<\/li>\n<\/ul>\n\n\n\n<p><strong><u><strong>Choice A and B<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ol style=\"list-style-type:lower-alpha\" class=\"wp-block-list\">\n<li>it is an independent risk factor for the outcome<\/li>\n<\/ol>\n\n\n\n<ul class=\"wp-block-list\">\n<li>it is a statistically significant predictor for the outcome<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>it differs in frequency between exposed and unexposed study subjects<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><u><strong>choices a and b<\/strong><\/u><\/strong><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>choices a and c<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>all of the above<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Using a diagram, show how the total sum of squares is partitioned in a 2-factor mixed ANOVA?<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-1.png\"><img loading=\"lazy\" decoding=\"async\" width=\"498\" height=\"298\" src=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-1.png\" alt=\"\" class=\"wp-image-37721\" srcset=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-1.png 498w, https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-1-300x180.png 300w\" sizes=\"auto, (max-width: 498px) 100vw, 498px\" \/><\/a><\/figure>\n\n\n\n<p>For question 10: Replace the small response line with your fill-in response <strong>(black, bold).<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Part 1: <strong><u><strong>Mantel-Haenszel method<\/strong><\/u><\/strong>\u00a0is used to analyze matched-pair case-control studies with multiple confounding variables.<\/li>\n<\/ol>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p>Part 2: <strong><u><strong>Multiple regression analysis<\/strong><\/u><\/strong>&nbsp;is used to analyze cohort studies with multiple confounding variables.<\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p>Part III. Problems (10 points each)<\/p>\n\n\n\n<p>1.&nbsp; A study was performed to evaluate a potential relationship between diastolic blood pressure (DBP) and exercise minutes per week in a random sample of 11 subjects aged 20 to 29 years.<\/p>\n\n\n\n<p>The results were as follows:<\/p>\n\n\n\n<p>Exercise (min\/week) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;DBP (mm Hg)<\/p>\n\n\n\n<p>&nbsp;10 &nbsp;80<\/p>\n\n\n\n<p>&nbsp;20 &nbsp;73<\/p>\n\n\n\n<p>&nbsp;30 &nbsp;81<\/p>\n\n\n\n<p>&nbsp;40 &nbsp;83<\/p>\n\n\n\n<p>&nbsp;50 &nbsp;77<\/p>\n\n\n\n<p>&nbsp;60 &nbsp;75<\/p>\n\n\n\n<p>&nbsp;70 &nbsp;78<\/p>\n\n\n\n<p>&nbsp;80 &nbsp;77<\/p>\n\n\n\n<p>&nbsp;90 &nbsp;76<\/p>\n\n\n\n<p>100 &nbsp;72<\/p>\n\n\n\n<p>110 &nbsp;73<\/p>\n\n\n\n<p>Using the attached SAS file <strong>(SASfinal1.sas)<\/strong>, perform a simple linear regression analysis with the dependent variable, DBP, and independent predictor variable, Exmin\/week.<\/p>\n\n\n\n<p>Assume normality and equal variance. Use \u03b1 = 0.05 (two-tailed) and assume 60% power.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-2.png\"><img loading=\"lazy\" decoding=\"async\" width=\"363\" height=\"319\" src=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-2.png\" alt=\"\" class=\"wp-image-37722\" srcset=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-2.png 363w, https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-2-300x264.png 300w\" sizes=\"auto, (max-width: 363px) 100vw, 363px\" \/><\/a><\/figure>\n\n\n\n<ol style=\"list-style-type:lower-alpha\" class=\"wp-block-list\">\n<li>State the null and alternative hypotheses for testing the slope.<\/li>\n<\/ol>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Null hypothesis H<\/strong><strong><sub><strong><sub>o<\/sub><\/strong><\/sub><\/strong><strong>: \u03b2<\/strong><strong><sub><strong><sub>1 <\/sub><\/strong><\/sub><\/strong><strong>= 0<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Alternative hypothesis H<\/strong><strong><sub><strong><sub>a<\/sub><\/strong><\/sub><\/strong><strong>: \u03b2<\/strong><strong><sub><strong><sub>1 <\/sub><\/strong><\/sub><\/strong><strong>\u2260 0<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>List the critical value for testing the slope.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u><strong>t<\/strong><\/u><\/strong><strong><u><sub><strong><sub>c<\/sub><\/strong><\/sub><\/u><\/strong><strong><u><strong>&nbsp;=2.262<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>List the R<sup>2<\/sup>.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u><strong>R<\/strong><\/u><\/strong><strong><u><sup><strong><sup>2 <\/sup><\/strong><\/sup><\/u><\/strong><strong><u><strong>= 0.3107<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Replacing the response lines, report your decision (reject Ho and accept Ha OR fail to reject Ho) based on the critical value, P-value, and 95% confidence interval for the slope:<\/li>\n<\/ul>\n\n\n\n<p><strong><u><strong>Since t-statistic &lt; critical value, fail to reject Ho<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<p>_________________________________________________________________________<\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u><strong>Since P-value &gt; 0.05, fail to reject Ho<\/strong><\/u><\/strong><strong><u><strong>____________________________<\/strong><\/u><\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Since 95% CI includes the null value, fail to reject Ho<\/strong><strong><\/strong><\/p>\n\n\n\n<p>__________________________________________________________________________<\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>If the decision was to fail to reject Ho, can Ho be accepted?<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>No, the H<\/strong><strong><sub><strong><sub>o <\/sub><\/strong><\/sub><\/strong><strong>cannot be accepted. Failing to reject the null is not an indication that it is true. It only means that the test does not provide enough evidence to reject the null. <\/strong><strong><\/strong><\/p>\n\n\n\n<p>2. In an epidemiologic study, 147 incident breast cancer cases were compared to 179 controls selected from the population that gave rise to the cases with respect to alcohol consumption history. The data were as follows:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td rowspan=\"2\">Exposure status<\/td><td colspan=\"2\">Disease Status<\/td><td>&nbsp;<\/td><\/tr><tr><td>Case<\/td><td>Control<\/td><td>Total<\/td><\/tr><tr><td>&gt; 3 drinks\/day<\/td><td>75<\/td><td>87<\/td><td>162<\/td><\/tr><tr><td>Nondrinker<\/td><td>72<\/td><td>92<\/td><td>164<\/td><\/tr><tr><td>Total<\/td><td>147<\/td><td>179<\/td><td>326<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Perform the appropriate statistical test of the relationship between breast cancer and alcohol consumption history using the attached SAS file <strong>(SASfinal2.sas)<\/strong>. Assume \u03b1 = 0.05 (two-tailed) and 80% power.<\/p>\n\n\n\n<ol style=\"list-style-type:lower-alpha\" class=\"wp-block-list\">\n<li>State the null and alternative hypotheses.<\/li>\n<\/ol>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Null hypothesis H<\/strong><strong><sub><strong><sub>o<\/sub><\/strong><\/sub><\/strong><strong>: Disease status is independent of exposure status<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Alternative hypothesis H<\/strong><strong><sub><strong><sub>o<\/sub><\/strong><\/sub><\/strong><strong>: Disease status is dependent on exposure status<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>List the critical value.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" src=\"\" width=\"86\" height=\"16\"><strong><u><strong>&nbsp;= 3.841<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>List the estimated odds ratio.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>OR = 1.1015, 95% CI {0.7120, 1.7043}<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Replacing the response lines and using\u00a0the uncorrected chi-square, P-value, and odds ratio output from SAS, report your decision (reject Ho and accept H<sub>A<\/sub>\u00a0OR fail to reject Ho) based on the critical value, P-value, and 95% confidence interval for the odds ratio.<\/li>\n<\/ul>\n\n\n\n<p><strong>Since chi-square statistic &lt; critical value, fail to reject Ho<\/strong><strong><\/strong><\/p>\n\n\n\n<p>__________________________________________________________________________<\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Since P-value &gt; 0.05, fail to reject Ho<\/strong><strong><\/strong><\/p>\n\n\n\n<p>_______________________________________________________________________<\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Since 95% CI includes the null value, fail to reject Ho<\/strong><strong><\/strong><\/p>\n\n\n\n<p>_________________________________________________________________________<\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>If the decision was to fail to reject Ho, can Ho be accepted?<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>No, the H<\/strong><strong><sub><strong><sub>o <\/sub><\/strong><\/sub><\/strong><strong>cannot be accepted. Failing to reject the null is not an indication that it is true. It only means that the test does not provide enough evidence to reject the null. <\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Epidemiologic study results, expressed as point estimates with accompanying 95% confidence intervals, are shown in the diagram below. For A\u2013D, list the number of each description that applies to the confidence interval as follows:<\/li>\n<\/ul>\n\n\n\n<p>A: 1, 2, 3, 4, \u2026<\/p>\n\n\n\n<p>B: 1, 2, 3, 4, &#8230; and so on.<\/p>\n\n\n\n<p>Among A-D there are 10 total correct descriptions.<\/p>\n\n\n\n<p>Each correct description earns 1 point.<\/p>\n\n\n\n<p>Each incorrect description subtracts 1 point.<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Reject Ho<\/strong><\/li>\n\n\n\n<li><strong>Do not reject Ho<\/strong><\/li>\n\n\n\n<li><strong>Imprecision<\/strong><\/li>\n\n\n\n<li><strong>Accept Ho<\/strong><\/li>\n\n\n\n<li><strong>Likely type II error<\/strong><\/li>\n\n\n\n<li><strong>Cannot distinguish between benefit and harm<\/strong><\/li>\n\n\n\n<li><strong>Clear elevation of risk<\/strong><\/li>\n<\/ol>\n\n\n\n<p><strong>A: 2, 6<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>B: 2, 6, 7<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>C:1, 7<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>D: 2, 6, <\/strong><strong><\/strong><\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;RR =1<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/Capture.png\"><img loading=\"lazy\" decoding=\"async\" width=\"445\" height=\"331\" src=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/Capture.png\" alt=\"\" class=\"wp-image-37726\" srcset=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/Capture.png 445w, https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/Capture-300x223.png 300w\" sizes=\"auto, (max-width: 445px) 100vw, 445px\" \/><\/a><\/figure>\n\n\n\n<p>In Module 5 (Slide 12) we used a two-sample t-test to compare the mean resting heart rate for normal males aged 40-59 in city A to the mean resting heart rate for normal males aged 40-59 in city B. (10 points)<br><br>The data were as follows:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td colspan=\"2\">City A<\/td><td colspan=\"2\">City B<\/td><\/tr><tr><td>Age (yr)<\/td><td>HR (beats\/min)<\/td><td>Age (yr)<\/td><td>HR (beats\/min)<\/td><\/tr><tr><td>52<\/td><td>71<\/td><td>67<\/td><td>74<\/td><\/tr><tr><td>67<\/td><td>83<\/td><td>61<\/td><td>69<\/td><\/tr><tr><td>58<\/td><td>74<\/td><td>60<\/td><td>69<\/td><\/tr><tr><td>51<\/td><td>66<\/td><td>62<\/td><td>71<\/td><\/tr><tr><td>59<\/td><td>75<\/td><td>59<\/td><td>70<\/td><\/tr><tr><td>53<\/td><td>70<\/td><td>63<\/td><td>73<\/td><\/tr><tr><td>58<\/td><td>76<\/td><td>61<\/td><td>72<\/td><\/tr><tr><td>61<\/td><td>78<\/td><td>56<\/td><td>59<\/td><\/tr><tr><td>49<\/td><td>69<\/td><td>69<\/td><td>76<\/td><\/tr><tr><td>64<\/td><td>80<\/td><td>60<\/td><td>68<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Note: Age of the study subjects was not included in the original dataset.<\/p>\n\n\n\n<p>Assume normality and equal variance. Use \u03b1 = 0.05 (two-tailed).<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-3.png\"><img loading=\"lazy\" decoding=\"async\" width=\"291\" height=\"267\" src=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-3.png\" alt=\"\" class=\"wp-image-37723\"\/><\/a><\/figure>\n\n\n\n<p>Using the attached SAS file <strong>(SASfinal4.sas)<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>State the null and alternative hypotheses for an unadjusted two-sample t-test comparing HR between city A and city B.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Null hypothesis H<\/strong><strong><sub><strong><sub>o<\/sub><\/strong><\/sub><\/strong><strong>: The mean resting heart rate for males aged 40-59 is equal in City A and City B. i.e., \u00b5<\/strong><strong><sub><strong><sub>A<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;= \u00b5<\/strong><strong><sub><strong><sub>B<\/sub><\/strong><\/sub><\/strong><strong><sub><strong><sub><\/sub><\/strong><\/sub><\/strong><\/p>\n\n\n\n<p><strong>Alternative hypothesis H<\/strong><strong><sub><strong><sub>a<\/sub><\/strong><\/sub><\/strong><strong>: The mean resting heart rate for males aged 40-59 is not equal in City A and City B. i.e., \u00b5<\/strong><strong><sub><strong><sub>A<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;\u2260 \u00b5<\/strong><strong><sub><strong><sub>B<\/sub><\/strong><\/sub><\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>List the critical value.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u><strong>t<\/strong><\/u><\/strong><strong><u><sub><strong><sub>c<\/sub><\/strong><\/sub><\/u><\/strong><strong><u><strong>&nbsp;=2.101<\/strong><\/u><\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Replacing the response line, report your decision (reject Ho and accept Ha OR fail to reject Ho) based on the critical value.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX <\/strong><strong><\/strong><\/p>\n\n\n\n<p>_<strong><u><strong>Since t-statistic &lt; critical value, fail to reject Ho<\/strong><\/u><\/strong><strong><u><strong><\/strong><\/u><\/strong><\/p>\n\n\n\n<p>To adjust for potential confounding due to age, a 1-way ANCOVA model was fit to the data.<\/p>\n\n\n\n<p>In the test for interaction between the covariate (age) and treatment (city A vs. city B):<\/p>\n\n\n\n<p>Full Model: Y = \u03b2<sub>1<\/sub>X<sub>1<\/sub>&nbsp;+ \u03b2<sub>2<\/sub>X<sub>2<\/sub>&nbsp;+ \u03b2<sub>3<\/sub>X<sub>1<\/sub>X<sub>2<\/sub>&nbsp;+ \u03b5<\/p>\n\n\n\n<p>Reduced Model: Y = \u03b2<sub>1<\/sub>X<sub>1<\/sub>&nbsp;+ \u03b2<sub>2<\/sub>X<sub>2<\/sub>&nbsp;+ \u03b5<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-4.png\"><img loading=\"lazy\" decoding=\"async\" width=\"268\" height=\"322\" src=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-4.png\" alt=\"\" class=\"wp-image-37724\" srcset=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-4.png 268w, https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-4-250x300.png 250w\" sizes=\"auto, (max-width: 268px) 100vw, 268px\" \/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li>State the null and alternative hypotheses for the test for interaction.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Null hypothesis H<\/strong><strong><sub><strong><sub>o<\/sub><\/strong><\/sub><\/strong><strong>: There is no interaction between age and city. i.e., \u03b2<\/strong><strong><sub><strong><sub>3<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;= 0<\/strong><strong><sub><strong><sub><\/sub><\/strong><\/sub><\/strong><\/p>\n\n\n\n<p><strong>Alternative hypothesis H<\/strong><strong><sub><strong><sub>a<\/sub><\/strong><\/sub><\/strong><strong>: There is an interaction between age and city. i.e., \u03b2<\/strong><strong><sub><strong><sub>3<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;\u2260 0<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>From the SAS output, what is the estimate for the interaction term (age*city)?<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u03b2<\/strong><strong><sub><strong><sub>3<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;= 0.1825<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Is the interaction term statistically significant?<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>No, the interaction is not statistically significant because p &gt;0.05. <\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can the ANCOVA process proceed?<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Yes, the ANCOVA Process can proceed for the main effects because the interaction is not statistically significant. <\/strong><strong><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-5.png\"><img loading=\"lazy\" decoding=\"async\" width=\"370\" height=\"290\" src=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-5.png\" alt=\"\" class=\"wp-image-37725\" srcset=\"https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-5.png 370w, https:\/\/myassignmenthelp.info\/assignments\/wp-content\/uploads\/2025\/01\/image-5-300x235.png 300w\" sizes=\"auto, (max-width: 370px) 100vw, 370px\" \/><\/a><\/figure>\n\n\n\n<p>In the test for the age-adjusted treatment effect:<\/p>\n\n\n\n<p>Full Model: Y = \u03b2<sub>1<\/sub>X<sub>1<\/sub>&nbsp;+ \u03b2<sub>2<\/sub>X<sub>2<\/sub>&nbsp;+ \u03b5<\/p>\n\n\n\n<p>Reduced Model: Y = \u03b2<sub>1<\/sub>X<sub>1<\/sub>&nbsp;+ \u03b5<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>State the null and alternative hypotheses for the test of adjusted treatment difference.<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>Null hypothesis H<\/strong><strong><sub><strong><sub>o<\/sub><\/strong><\/sub><\/strong><strong>: There is no difference in adjusted mean heart rates between City A and City B. i.e., \u03b2<\/strong><strong><sub><strong><sub>2<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;= 0<\/strong><strong><sub><strong><sub><\/sub><\/strong><\/sub><\/strong><\/p>\n\n\n\n<p><strong>Alternative hypothesis H<\/strong><strong><sub><strong><sub>a<\/sub><\/strong><\/sub><\/strong><strong>: There is a significant difference in age-adjusted mean heart rates between City A and City B. i.e., \u03b2<\/strong><strong><sub><strong><sub>2<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;\u2260 0<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>From the SAS output, what is the estimate for the adjusted treatment effect (city)?<\/li>\n<\/ul>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u03b2<\/strong><strong><sub><strong><sub>2<\/sub><\/strong><\/sub><\/strong><strong>&nbsp;= -8.3413<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Is the age-adjusted treatment effect statistically significant?<\/li>\n<\/ul>\n\n\n\n<p><strong>Yes, the age-adjusted treatment effect is statistically significant because p&lt;0.05<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>XXX<\/strong><strong><\/strong><\/p>\n\n\n<p><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359],"tags":[],"class_list":["post-37719","post","type-post","status-publish","format-standard","hentry","category-education"],"_links":{"self":[{"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/posts\/37719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/comments?post=37719"}],"version-history":[{"count":1,"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/posts\/37719\/revisions"}],"predecessor-version":[{"id":37727,"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/posts\/37719\/revisions\/37727"}],"wp:attachment":[{"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/media?parent=37719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/categories?post=37719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/myassignmenthelp.info\/assignments\/wp-json\/wp\/v2\/tags?post=37719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}