Literature Review: 1023970

Literature review

Formation of liver fibrosis.
Use of biomarkers of fibrosis in different stages
Grad score of fibrosis 1.

  1. Biopsy and diagnosis of liver fibrosis
  2. Comparison of biopsy and biomarker

6.Pitfalls of liver biopsy

What are the biomarkers for

Types of biomarkers

Biomarker Development

Biomarker Prognosis

  1. Biomarker Interpretation

Pitfalls in Biomarkers

Hepatitis C

Hepatitis B

Non-alcoholic liver disease

Alcoholic Liver Disease

Sequential Algorithm


Genetic Markers


Thus, it is concluded that liver fibrosis can occur due to the various viral infection that can change the pathology of the organ. This change is related to a number of other changes like accumulation of fat, scar. This changes can be identified by the use of various techniques including biomarkers, genetic markers and proteomics. These techniques gives a clear image about the pathogenesis of the disease and helps in the proper diagnosis of the disease.


Ahmed, A., Wong, R.J. and Harrison, S.A., 2015. Nonalcoholic fatty liver disease review: diagnosis, treatment, and outcomes. Clinical Gastroenterology and Hepatology, 13(12), pp.2062-2070.
Amato, R., Lim, P., Miotto, O., Amaratunga, C., Dek, D., Pearson, R.D., Almagro-Garcia, J., Neal, A.T., Sreng, S., Suon, S. and Drury, E., 2017. Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study. The Lancet Infectious Diseases, 17(2), pp.164-173.
Bernuth, S., Yagmur, E., Schuppan, D., Sprinzl, M. F., Zimmermann, A., Schad, A., … & Wörns, M. A. (2016). Early changes in dynamic biomarkers of liver fibrosis in hepatitis C virus-infected patients treated with sofosbuvir. Digestive and Liver Disease, 48(3), 291-297.
Calès, P., Sacher‐Huvelin, S., Valla, D., Bureau, C., Olivier, A., Oberti, F., Boursier, J., Galmiche, J.P. and multicenter group VO‐VCO, 2018. Large oesophageal varice screening by a sequential algorithm using a cirrhosis blood test and optionally capsule endoscopy. Liver International, 38(1), pp.84-93.

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., … & Xiang, J. (2015). Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature cell biology, 17(6), 816.
Enomoto, H., Bando, Y., Nakamura, H., Nishiguchi, S., & Koga, M. (2015). Liver fibrosis markers of nonalcoholic steatohepatitis. World Journal of Gastroenterology: WJG, 21(24), 7427.
Gangadharan, B., Kumar, A., Barnes, E., Klenerman, P., Dwek, R. and Zitzmann, N., 2016. The Use of Proteomics in Diagnostics: Liver Fibrosis Biomarkers. Journal of Pathology, 240(Supplement S1).
Hardy, T., Zeybel, M., Day, C. P., Dipper, C., Masson, S., McPherson, S., … & Mann, D. A. (2017). Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. Gut, 66(7), 1321-1328.